Letter by Madias Regarding Article, “Hypertrophic Cardiomyopathy–Related Sudden Cardiac Death in Young People in Ontario”

Letter by Sheppard et al Regarding Article, "Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death".

To the Editor: We read with great interest the excellent article by Basso et al on arrhythmic mitral valve prolapse (MVP) and sudden cardiac death in Circulation. The investigators reported a relatively high prevalence of MVP in individuals experiencing sudden death. Such deaths were more common in young women and were associated with myocardial fibrosis in the papillary muscles and the inferob...

Sudden cardiac death in young people.

consensus of opinion. Background Surveys of sudden death in England suggest that 3,500 unexpected sudden deaths occur per annum in the 16-64 age group. Of these the majority are due to c o ro n a ry art e ry disease but in 4.1% a coro n e r’s post-mortem is unable to find evidence of structural cardiac disease or significant drug exposure. The cause of death is therefore unascertainable. These ...

Letter by Providencia and Lambiase Regarding Article, "Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death".

BACKGROUND Mitral valve prolapse (MVP) may present with ventricular arrhythmias and sudden cardiac death (SCD) even in the absence of hemodynamic impairment. The structural basis of ventricular electric instability remains elusive. METHODS AND RESULTS The cardiac pathology registry of 650 young adults (≤40 years of age) with SCD was reviewed, and cases with MVP as the only cause of SCD were r...

Sudden death in young people due to hypertrophic cardiomyopathy.

Letter regarding article by Burke et al, "role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks".

BACKGROUND The Y1102 polymorphism of the cardiac sodium channel (SCN5A) gene has been found in 13% of black Americans. It has been linked to lethal arrhythmias in black families with ventricular tachycardia. The prevalence of the Y1102 polymorphism in a series of sudden death in blacks is unknown. METHODS AND RESULTS We investigated the incidence of the Y1102 polymorphism in a series of 289 s...